That's the rub phrase
That is the biggest or most difficult problem (with the situation being discussed)
A: "Why don't you buy something to eat, man?" B: "That's the rub! I don't have any money left."
A: "You really should get your life together!" B: "That's the rub, man! I don't know what to do right now."
A problem or difficult circumstance
To have to accept some troubles or worries that must be handled by oneself
Completely controlling over a scenario or situation.
This is a line from Shakespeare's Hamlet:
"To die — to sleep.
To sleep — perchance to dream: ay, there’s the rub!
For in that sleep of death what dreams may come
When we have shuffled off this mortal coil,
Must give us pause."
Used to allude that the last force, problem or burden which is seemingly minor and small causes a person, system or organisation to collapse or fail
Her husband's violent act last night was the straw that broke the donkey's back and she left him